Relationship Between Low Birth Weight and Neonatal Jaundice: Retrospective Case-Control Study at Wates Regional Hospital
Abstract
Introduction: Neonatal mortality is a critical indicator of public health and reflects the quality of maternal and neonatal healthcare services in a country. Low birth weight (LBW) and neonatal jaundice are among the leading causes of neonatal morbidity. This research aims to investigates the relationship between LBW and the incidence of neonatal jaundice in infants treated at the NICU of RSUD Wates, Kulon Progo, Yogyakarta. The findings will inform evidence-based policies and targeted interventions for Kulon Progo and surrounding areas.
Methods: This quantitative analytical study employed a retrospective case-control design. Data were collected from medical records of neonates admitted at the NICU of RSUD Wates from January to April 2023. A total of 200 neonates were selected using purposive sampling based on the study's criteria. Data analysis was performed using SPSS 25, with chi-square tests to examine the relationship between LBW and neonatal jaundice.
Results: The analysis revealed that 35% of infants were LBW, and 28% experienced neonatal jaundice. The chi-square test showed a significant association between LBW and neonatal jaundice, with a p-value of < 0.001. Infants with LBW were 4.15 times more likely to develop jaundice compared to those with normal birth weight.
Conclusion: This condition is a major contributor to the development of neonatal jaundice, with a 4.15 fold increased risk. These findings highlight the importance of early detection and management of LBW to reduce the incidence of neonatal jaundice and improve neonatal outcomes, particularly in regions with high LBW prevalence.
References
Hug L, Alexander M, You D, Alkema L. National, regional, and global levels and trends in neonatal mortality between 1990 and 2017, with scenario-based projections to 2030: a systematic analysis. Lancet Glob Health. 2019 Jun 1;7(6):e710–20. https://doi.org/10.1016/S2214-109X(19)30163-9 PMID: 31097275
Beluzo CE, Silva E, Alves LC, Bresan RC, Arruda NM, Sovat R, et al. Towards neonatal mortality risk classification: A data-driven approach using neonatal, maternal, and social factors. Inform Med Unlocked. 2020 Jan 1;20. https://doi.org/10.1016/j.imu.2020.100398
Lawn JE, Bhutta ZA, Ezeaka C, Saugstad O. Ending Preventable Neonatal Deaths: Multicountry Evidence to Inform Accelerated Progress to the Sustainable Development Goal by 2030. Neonatology. 2023 Aug 1;120(4):491–9. https://doi.org/10.1159/000530496 PMID: 37231868
Slusher TM, Zamora TG, Appiah D, Stanke JU, Strand MA, Lee BW, et al. Burden of severe neonatal jaundice: A systematic review and meta-analysis. BMJ Paediatr Open. 2017 Dec 1;1(1). https://doi.org/10.1136/bmjpo-2017-000105
Anil KC, Basel PL, Singh S. Low birth weight and its associated risk factors: Health facility-based case-control study. PLoS One. 2020 Jun 1;15(6 June). https://doi.org/10.1371/journal.pone.0234907 PMID: 32569281
Jana A, Saha UR, Reshmi RS, Muhammad T. Relationship between low birth weight and infant mortality: evidence from National Family Health Survey 2019-21, India. Archives of Public Health. 2023 Dec 1;81(1). https://doi.org/10.1186/s13690-023-01037-y
Sampurna MTA, Handayani KD, Utomo MT, Angelika D, Etika R, Harianto A, et al. Determinants of neonatal deaths in Indonesia: A national survey data analysis of 10,838 newborns. Heliyon. 2023 Jan 1;9(1). https://doi.org/10.1016/j.heliyon.2023.e12980
Supriyanto Y, Paramashanti BA, Astiti D. Berat badan lahir rendah berhubungan dengan kejadian stunting pada anak usia 6-23 bulan. Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics). 2018 Jan 16;5(1):23. https://doi.org/10.21927/ijnd.2017.5(1).23-30
Maryam TS, Khairiah R. Efektifitas Pelaksanaan Perencanaan Persalinan dan Pencegahan Komplikasi (P4K) Pada Ibu Hamil Terhadap Proses Persalinan di Wilayah Kerja Puskesmas Parakannyasag Kota Tasikmalaya. Malahayati Nursing Journal. 2024 Feb 1;6(2):587–99. https://doi.org/10.33024/mnj.v6i2.10831
Silvestrin S, Da Silva CH, Hirakata VN, Goldani AAS, Silveira PP, Goldani MZ. Maternal education level and low birth weight: A meta-analysis. J Pediatr (Rio J). 2013;89(4):339–45. https://doi.org/10.1016/j.jped.2013.01.003 PMID: 23809705
Pandey AK, Thomas BM, Gautam D, Balachandran A, Widyastari DA, Sriram S, et al. Unraveling the complexity of selected adverse neonatal outcomes in India: a multilevel analysis using data from a nationally representative sample survey. BMC Pregnancy Childbirth. 2025 Dec 1;25(1). https://doi.org/10.1186/s12884-025-07448-9
Ja?czewska I, Wierzba J, Ja?czewska A, Szczurek-Gierczak M, Dom?alska-Popadiuk I. Prematurity and Low Birth Weight and Their Impact on Childhood Growth Patterns and the Risk of Long-Term Cardiovascular Sequelae. Children. 2023 Oct 1;10(10). https://doi.org/10.3390/children10101599
Baldassarre ME, Di Mauro A, Salvatore S, Tafuri S, Bianchi FP, Dattoli E, et al. Birth weight and the development of functional gastrointestinal disorders in infants. Pediatr Gastroenterol Hepatol Nutr. 2020;23(4):366–76. https://doi.org/10.5223/pghn.2020.23.4.366
Itoh S, Okada H, Koyano K, Nakamura S, Konishi Y, Iwase T, et al. Fetal and neonatal bilirubin metabolism. Front Pediatr. 2023 Feb 9;10. https://doi.org/10.3389/fped.2022.1002408
Shaohua Y, Bin Z, Mei L, Jingfei Z, Pingping Q, Yanping H, et al. Maternal risk factors and neonatal outcomes associated with low birth weight. Front Genet. 2022 Sep 28;13. https://doi.org/10.3389/fgene.2022.1019321
Besli GE, Metin F, Aksit MA, Saltik S. Long-term effects of indirect hyperbilirubinemia on auditory and neurological functions in term newborns. Medeni Med J. 2020;35(1):29–39. https://doi.org/10.5222/MMJ.2020.26986
Jubella M, Taherong F, Alza N. Manajemen Asuhan Kebidanan Segera Bayi Baru Lahir Berkelanjutan pada Bayi Ny “M” dengan Ikterus Neonatorum Fisiologis di Rumah Sakit Umum Bahagia Makassar Tahun 2021. Jurnal Midwifery. 2022 Feb 26;4(1):65–76. https://doi.org/10.24252/jmw.v4i1.28001
Yasadipura CC, Suryawan IWB, Sucipta AAM. Hubungan Bayi Berat Lahir Rendah (BBLR) dengan kejadian hiperbilirubinemia pada neonatus di RSUD Wangaya, Bali, Indonesia. Intisari Sains Medis. 2020 Dec 1;11(3):1277–81. https://doi.org/10.15562/ism.v11i3.706
Jaya Am, Fauziah H. Hubungan Berat Badan Lahir Rendah (BBLR) dengan Hiperbilirubinemia di Rumah Sakit Wilayah Kota Makassar Periode Januari-Desember Tahun 2018. UMI Medical Journal . 2021;6(2):130–6.
Latifah L, Aryuti Nirmala S, Astuti S. Hubungan Antara Bayi Berat Lahir Rendah Dengan Kejadian Ikterus Di Rumah Sakit Umum Daerah Soreang Periode Januari-Desember Tahun 2015. Jurnal Bidan "Midwife Journal [Internet]. 2017;3(02).
Lewallen S, Courtright P. Epidemiology in Practice: Case-Control Studies. Community Eye Health [Internet]. 1998 [cited 2025 Apr 24];11(28):57–8.
de Sanctis V, Soliman AT, Daar S, Tzoulis P, Fiscina B, Kattamis C, et al. Retrospective observational studies: Lights and shadows for medical writers. Acta Biomedica. 2022;93(5). https://doi.org/10.23750/abm.v93i5.13179
Bellieni C. The Best Age for Pregnancy and Undue Pressures [Internet]. Vol. 10, Journal of Family and Reproductive Health ?. 2016.
Indah FN, Utami I. Faktor-Faktor Yang Berhubungan Dengan Kejadian Berat Badan Lahir Rendah (BBLR). Jurnal Ilmiah Keperawatan [Internet]. 2020 [cited 2025 Apr 24];8(1).
Handayani F, Fitriani H, Lestari CI. Hubungan Umur Ibu Dan Paritas Dengan Kejadian Bblr Di Wilayah Puskesmas Wates Kabupaten Kulon Progo. Midwifery Journal | Kebidanan. 2019;4(2):67–70.
Diabelková J, Rimárová K, Urdzík P, Dorko E, Houžvi?ková A, Andraš?íková Š, et al. Risk Factors Associated With Low Birth Weight. Cent Eur J Public Health. 2022 Jun 1;30:S43–9. https://doi.org/10.21101/cejph.a6883 PMID: 35841225
Rahayuningtyas Y. Hubungan Berat Badan Lahir Dengan Kejadian Ikterus Neonatorum di Ruang Perinatologi RSD dr. Soebandi Jember. [Indonesia]: Universitas Muhammadiyah Jember; 2020.
Yuliana, Idawati, Agustina J. Pengaruh Berat Badan Lahir, Asfiksia Dan Jenis Persalinan Terhadap Kejadian Ikterus Pada Neonatus Di Rumah Sakit Umum Daerah Tgk Chik Ditiro Sigli Kabupaten Pidie. Serambi Akademica Jurnal Pendidikan, Sains, dan Humaniora. 2023;11(1):15–24.
Rafie R, Nopiyanti A. Pengaruh Berat Badan Lahir Rendah Terhadap Ikterus Neonatorum Pada Neonatus Di Ruang Perinatologi Rsud Karawang Provinsi Jawa Barat Tahun 2016. Jurnal Ilmu Kedokteran Dan Kesehatan. 2017;4(1):12–7.
Ali R, Ahmed S, Qadir M, Ahmad K. Icterus Neonatorum in Near-Term and Term Infants An overview. SQU Med J. 2012;12(2):153–60. https://doi.org/10.12816/0003107
Agustin AD, Afrika E. Faktor-Faktor Yang Berhubungan Dengan Kejadian Berat Badan Lahir Rendah (Bblr) Di Wilayah Kerja Puskesmas Muara Burnai. PREPOTIF Jurnal Kesehatan Masyarakat. 2022;6(2):1042–9.
Ullah S, Rahman K, Hedayati M. Hyperbilirubinemia in Neonates: Types, Causes, Clinical Examinations, Preventive Measures and Treatments: A Narrative Review Article. Iran J Public Health [Internet]. 2016;45(5):558–68.
Das S, van Landeghem FKH. Clinicopathological spectrum of bilirubin encephalopathy/kernicterus. Diagnostics. 2019 Mar 1;9(1). https://doi.org/10.3390/diagnostics9010024
Heringguhir SA, Maelissa MM, Djoko SW. Hubungan Usia Gestasi Dan Berat Lahir Neonatus Dengan Kejadian Ikterus Neonatorum Di Rsud Dr.M.Haulussy Ambon Tahun 2018-2020. Patimura Medical Review (PAMERI) [Internet]. 2022 [cited 2025 Apr 24];4(2):53–4. https://doi.org/10.32672/jsa.v11i1.5678
Cohen RS, Wong RJ, Stevenson DK. Understanding neonatal jaundice: A perspective on causation. Pediatr Neonatol. 2010 Jun;51(3):143–8. https://doi.org/10.1016/S1875-9572(10)60027-7 PMID: 20675237
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