Spatio-Temporal Analysis of Tuberculosis Clusters in a Region of Topographic Diversity: A Case Study from West Sulawesi Province, Indonesia
Keywords:
Tuberculosis, Geospatial Analysis, Spatiotemporal, Topographical Diversity
Abstract
Introduction: Several studies on tuberculosis (TB) using spatial and time clustering analyses have been conducted in Indonesia, however none have specifically focused on regions characterized by diverse topography. This study aimed to identify geospatial clusters of TB cases in West Sulawesi Province, Indonesia, an area known for its topographic variability.
Methods: An ecological study design was employed. TB case data, including bacteriologically confirmed and clinically diagnosed cases, were obtained from the Tuberculosis Information System (Sistem Informasi Tuberkulosis, SITB) of the West Sulawesi Provincial Health Office, covering the period from January 1, 2020, to December 31, 2023. Spatial visualization was performed using QGIS version 3.40.0. Cluster detection and spatial pattern analysis were conducted using SaTScan version 10.2.5.
Results: TB cases in West Sulawesi formed clusters. A total of 17 clusters were identified—4 primary (most likely) clusters and 13 secondary clusters. In 2020, the primary cluster was located in Bambang Village, Bambang Subdistrict. In 2021, the primary cluster was in Lambanan Village, Mamasa Subdistrict. In 2022, the primary cluster was in Ulumambi Barat Village, Bambang Subdistrict, and in 2023, the primary cluster was again in Lambanan Village, Mamasa Subdistrict.
Conclusion: This study found that the most likely TB clusters from 2020 to 2023 were consistently located in the eastern part of West Sulawesi Province, specifically in Mamasa Regency, an area characterized by mountainous terrain. This suggests that various environmental, social, and economic factors unique to mountain communities may influence TB transmission dynamics. The findings highlight the need for geographically tailored intervention strategies, including mobile TB services, community-based education, enhanced surveillance systems, the establishment of local TB support networks, and improved healthcare infrastructure adapted to mountainous areas. Future research should consider integrating genotypic, molecular, and geospatial approaches to advance global TB control efforts.
References
[1] A. Meimela, “Modeling Of The Number Of Tuberculosis Cases In Indonesia,” J. Litbang Sukowati Media Penelit. dan Pengemb., vol. 4, no. 2, pp. 79–85, May 2021, doi: 10.32630/sukowati.v4i2.204.
[2] World Helath Organizatiaon, Global Tuberculosis Report 2024. 2024. [Online]. Available: https://iris.who.int/bitstream/handle/10665/379339/9789240101531-eng.pdf?sequence=1
[3] Kementrian Kesehatan RI, “Kasus TBC Tinggi Karena Perbaikan Sistem Deteksi dan Pelaporan.” Accessed: Nov. 24, 2024. [Online]. Available: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20240129/2644877/kasus-tbc-tinggi-karena-perbaikan-sistem-deteksi-dan-pelaporan/
[4] Dinas Kesehatan Provinsi Sulawesi Barat, “Upaya Penanggulangan Tuberkulosis di Sulawesi Barat: Langkah Menuju Bebas TBC 2030,” 2024. [Online]. Available: https://dinkes.sulbarprov.go.id/upaya-penanggulangan-tuberkulosis-di-sulawesi-barat-langkah-menuju-bebas-tbc-2030/
[5] F. Islam et al., “Factors Affecting Treatment Adherence Among Patients with Tuberculosis in Indonesia: Literature Review,” J. Public Heal. Pharm., vol. 4, no. 1, pp. 28–37, Mar. 2024, doi: 10.56338/jphp.v4i1.5022.
[6] A. Prameswari, “Urgensi Penanggulangan TBC di Indonesia.” Accessed: Nov. 24, 2024. [Online]. Available: https://rc-gerid.unair.ac.id/id/urgensi-penanggulangan-tbc-di-indonesia/
[7] M. S. Ramadhani, S. Suhartono, and O. Setiani, “Gambaran Sebaran Kasus Tuberkulosis Dalam Pendekatan Spasial Dan Temporal,” J. Kesehat. Masy., vol. 9, no. 4, pp. 529–540, Aug. 2021, doi: 10.14710/jkm.v9i4.30078.
[8] H. H. D. Lasari, I. Medyna, N. A. Fadillah, D. Rosadi, and R. Fakhriadi, “Spatio-temporal analysis of tuberculosis in Sungai Tabuk District, South Kalimantan, 2020-2021,” IOP Conf. Ser. Earth Environ. Sci., vol. 1239, no. 1, p. 012024, Sep. 2023, doi: 10.1088/1755-1315/1239/1/012024.
[9] Y. Yu, B. Wu, C. Wu, Q. Wang, D. Hu, and W. Chen, “Spatial-temporal analysis of tuberculosis in Chongqing, China 2011-2018,” BMC Infect. Dis., vol. 20, no. 1, p. 531, Dec. 2020, doi: 10.1186/s12879-020-05249-3.
[10] K. Chinpong et al., “Spatiotemporal Epidemiology of Tuberculosis in Thailand from 2011 to 2020,” Biology (Basel)., vol. 11, no. 5, p. 755, May 2022, doi: 10.3390/biology11050755.
[11] H. I. Zebua and I. G. N. M. Jaya, “Spatial Autoregressive Model of Tuberculosis Cases in Central Java Province 2019,” CAUCHY J. Mat. Murni dan Apl., vol. 7, no. 2, pp. 240–248, Mar. 2022, doi: 10.18860/ca.v7i2.13451.
[12] R. Tanjung, E. L. Mahyuni, N. Tanjung, O. S. Simarmata, J. Sinaga, and H. R. Nolia, “The Spatial Distribution of Pulmonary Tuberculosis in Kabanjahe District, Karo Regency, Indonesia,” Open Access Maced. J. Med. Sci., vol. 9, no. E, pp. 817–822, Sep. 2021, doi: 10.3889/oamjms.2021.6808.
[13] F. Fahdhienie, F. Y. Sitepu, and E. B. Depari, “Tuberculosis in Aceh Province, Indonesia: a spatial epidemiological study covering the period 2019–2021,” Geospat. Health, vol. 19, no. 2, Sep. 2024, doi: 10.4081/gh.2024.1318.
[14] S. Fitriyani and M. Sari, “Analisis Spasial Temporal Sosiodemografi Dan Variabilitas Iklim Terhadap Kejadian Tuberkulosis Paru BTA Positif di Provinsi Jawa Barat Tahun 2013-2017,” J. Untuk Masy. Sehat, vol. 5, no. 2, pp. 2715–8748, 2021, [Online]. Available: http://ejournal.urindo.ac.id/index.php/jukmas
[15] N. Hasnanisa, S. Prasetyo, and H. Yolanda, “Faktor-faktor Tuberkulosis Paru: Analisis Spasial,” Jikm, vol. 15, no. 3, pp. 107–118, 2023, [Online]. Available: https://jikm.upnvj.ac.id/index.php/home/article/view/466/160
[16] M. Tuntun, S. Aminah, and Yusrizal CH, “Distribution pattern and spatial analysis of factors for tuberculosis (TB) cases in Bandar Lampung City in 2022,” Bali Med. J., vol. 12, no. 1, pp. 50–58, Dec. 2022, doi: 10.15562/bmj.v12i1.3918.
[17] A. C. K. Nahak, I. A. T. Hinga, H. I. Ndoen, and Y. K. Samruth, “Spatial Analysis of Pulmonary Tuberculosis Incidence in Kupang City in 2019-2021,” J. Public Heal. Trop. Coast. Reg., vol. 7, no. 1, pp. 83–95, Apr. 2024, doi: 10.14710/jphtcr.v7i1.20682.
[18] D. S. Rosady, N. R. A. Zulfa, and S. B. Pratama, “Epidemiologic Spatial Analysis of a Tuberculosis Incidence in Bandung City in 2021,” Glob. Med. Heal. Commun., vol. 12, no. 1, pp. 31–36, Apr. 2024, doi: 10.29313/gmhc.v12i1.12410.
[19] A. F. Nurqanita et al., “Spatial and Epidemiological Analysis of Tuberculosis Incidence in Children in Palembang City in 2022,” J. Kesehat., vol. 17, no. 1, pp. 25–36, May 2024, doi: 10.23917/jk.v17i1.3004.
[20] T. B. Purnama, T. Kamigaki, M. Minsarnawati, and H. Oshitani, “Spatial Distribution of Tuberculosis in the Western Region of Java Island, Indonesia,” J. Heal. Sci. Med. Res., vol. 41, no. 1, p. 1, Dec. 2022, doi: 10.31584/jhsmr.2022889.
[21] D. N. S. Diba, B. Murti, and N. A. Setiyadi, “Spatial Analysis of Pulmonary Tuberculosis Risk in Surakarta , Central Java , Indonesia,” J. Epidemiol. Public Heal., vol. 09, no. 3, pp. 386–406, 2024, [Online]. Available: https://jepublichealth.com/index.php/jepublichealth/article/view/722/421
[22] P. Septiani, “Spatial Autocorrelation Analysis Of Pulmonary Tuberculosis Cases in Central Java Province,” J. Biometrika dan Kependud. (Journal Biometric Popul., vol. 13, no. 1, pp. 90–99, 2024, [Online]. Available: https://e-journal.unair.ac.id/JBK/article/view/50069/29295
[23] S. Khodijah and A. Prabawa, “Spatial Analysis of Risk Factors for Tuberculosis Incidence in South Jakarta City in 2022,” MPPKI Media Publ. Promosi Kesehat. Indones. " Indones. J. Heal. Promot., vol. 7, no. 6, pp. 1518–1524, 2024, [Online]. Available: https://jurnal.unismuhpalu.ac.id/index.php/MPPKI/article/view/5208/4018
[24] A. S. Cahyaningrum and N. A. Setiyadi, “Geo-Spatial Cluster Tuberkulosis of 2021-2023: Study in a District, Indonesia,” Indones. J. Glob. Heal. Res., vol. 6, no. 5, pp. 2863–2872, Nov. 2025, [Online]. Available: https://jurnal.globalhealthsciencegroup.com/index.php/IJGHR/article/view/3609/2610
[25] T. Puspita et al., “Spatial Variation of Tuberculosis Risk in Indonesia 2010-2019,” Heal. Sci. J. Indones., vol. 12, no. 2, pp. 104–110, Dec. 2021, doi: 10.22435/hsji.v12i2.5467.
[26] N. A. Mohidem, M. Osman, Z. Hashim, F. M. Muharam, S. Mohd Elias, and R. Shaharudin, “Association of sociodemographic and environmental factors with spatial distribution of tuberculosis cases in Gombak, Selangor, Malaysia,” PLoS One, vol. 16, no. 6, p. e0252146, Jun. 2021, doi: 10.1371/journal.pone.0252146.
[27] D. W. S. R. Wardani, L. Lazuardi, Y. Mahendradhata, and H. Kusnanto, “Pentingnya Analisis Cluster Berbasis Spasial dalam Penanggulangan Tuberkulosis di Indonesia,” Kesmas Natl. Public Heal. J., vol. 8, no. 4, p. 147, Nov. 2013, doi: 10.21109/kesmas.v0i0.391.
[28] Badan Pusat Statistik Sulawesi Barat, “Provinsi Sulawesi Barat dalam Angka,” 2024. [Online]. Available: https://sulbar.bps.go.id/id/publication/2024/02/28/8fdd58f5dce1137aaf1f1632/provinsi-sulawesi-barat-dalam-angka-2024.html
[29] Dinas Kesehatan Provinsi Sulawesi Barat, “Laporan Sistem Informasi Tuberkulosis,” 2024.
[30] SaTScanTM, “SaTScanTM Software for the spatial, temporal, and space-time scan statistics: ‘Download SaTScan For Windows.’” Accessed: Jul. 10, 2024. [Online]. Available: https://www.satscan.org/download_satscan.html
[31] I. Gwitira, N. Karumazondo, M. D. Shekede, C. Sandy, N. Siziba, and J. Chirenda, “Spatial patterns of pulmonary tuberculosis (TB) cases in Zimbabwe from 2015 to 2018,” PLoS One, vol. 16, no. 4, p. e0249523, Apr. 2021, doi: 10.1371/journal.pone.0249523.
[32] QGIS Development Team, “Download QGIS For Your Platform,” QGIS. Accessed: Nov. 17, 2023. [Online]. Available: https://www.qgis.org/download/
[33] Y.-P. Yeh, H.-J. Chang, J. Yang, S.-H. Chang, J. Suo, and T. H.-H. Chen, “Incidence of Tuberculosis in Mountain Areas and Surrounding Townships: Dose–Response Relationship by Geographic Analysis,” Ann. Epidemiol., vol. 15, no. 7, pp. 526–532, Aug. 2005, doi: 10.1016/j.annepidem.2004.08.005.
[34] M. Rezky, “Analisis Spasial Kejadian Tuberkulosis di Daerah Dataran Tinggi Kabupaten Gowa,” Universitas Islam Negeri Alauddin Makassar, 2017. [Online]. Available: https://repositori.uin-alauddin.ac.id/11438/1/MULI REZKY 70200113122.pdf
[35] M. SAITO et al., “Comparison of Altitude Effect on Mycobacterium Tuberculosis Infection Between Rural and Urban Communities in Peru,” Am. J. Trop. Med. Hyg., vol. 75, no. 1, pp. 49–54, Jul. 2006, doi: 10.4269/ajtmh.2006.75.49.
[36] K. T. Aulia and S. K. Yuniati, “The Effect of Population Density on The Risk of Tuberculosis in Densely Populated Environments,” J. Divers. Med. Res., vol. 1, no. 2, pp. 7–12, 2024, [Online]. Available: https://medicosphere.upnjatim.ac.id/index.php/medicosphere/article/view/96/29
[37] W. Hasan, “Penggunaan sistem informasi geografis untuk pemetaan sebaran kasus dan faktor risiko kejadian penyakit tb. Paru bta (+) di kabupaten majene,” J. Inf. Syst. Public Heal., vol. 4, no. 3, p. 40, Oct. 2021, doi: 10.22146/jisph.25863.
[38] S. E. Saqib and M. M. Ahmad, “Socio-economic determinants of the family history of pulmonary tuberculosis patients in Pakistan,” Dev. Pract., vol. 29, no. 1, pp. 103–114, Jan. 2019, doi: 10.1080/09614524.2018.1516737.
[39] H. Li, M. Ge, and M. Zhang, “Spatio-temporal distribution of tuberculosis and the effects of environmental factors in China,” BMC Infect. Dis., vol. 22, no. 1, p. 565, Dec. 2022, doi: 10.1186/s12879-022-07539-4.
[40] A. Baughman and E. Arens, “Indoor Humidity and Human Health-Part I: Literature Review of Health Effects of Humidity-Influenced Indoor Pollutants,” ASHRAE Trans., vol. 102, 1996, [Online]. Available: https://escholarship.org/uc/item/5kz1z9cg
[41] Y.-J. LIN and C.-M. LIAO, “Seasonal dynamics of tuberculosis epidemics and implications for multidrug-resistant infection risk assessment,” Epidemiol. Infect., vol. 142, no. 2, pp. 358–370, Feb. 2014, doi: 10.1017/S0950268813001040.
[42] A. G. Omonijo, O. Oguntoke, A. Matzarakis, and C. O. Adeofun, “A study of weather related respiratory diseases in eco-climatic zones,” African Rev. Phys., vol. 5, pp. 41–56, 2011, [Online]. Available: https://api.semanticscholar.org/CorpusID:33703549
[43] L. Xia et al., “Spatio-temporal analysis of socio-economic characteristics for pulmonary tuberculosis in Sichuan province of China, 2006–2015,” BMC Infect. Dis., vol. 20, no. 1, p. 433, Dec. 2020, doi: 10.1186/s12879-020-05150-z.
[44] N. A. Mohidem, M. Osman, Z. Hashim, F. M. Muharam, S. Mohd Elias, and A. Ma’pol, “Spatial Analysis of Identifying the Association between Risk Factors and Tuberculosis Cases: A Review,” Educ. J. Sci. Math. Technol., vol. 12, no. 1, pp. 24–34, Aug. 2024, doi: 10.37134/ejsmt.vol12.1.4.2025.
[45] T. K. A. Teibo, R. L. de P. Andrade, R. J. Rosa, R. B. V. Tavares, T. Z. Berra, and R. A. Arcêncio, “Geo-spatial high-risk clusters of Tuberculosis in the global general population: a systematic review,” BMC Public Health, vol. 23, no. 1, p. 1586, Aug. 2023, doi: 10.1186/s12889-023-16493-y.
[46] T. A. Campelo et al., “Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil,” Rev. Inst. Med. Trop. Sao Paulo, vol. 62, no. October 2019, pp. 1–10, 2020, doi: 10.1590/s1678-9946202062004.
[47] B. A. Cardoso et al., “Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon,” Rev. Inst. Med. Trop. Sao Paulo, vol. 59, no. May, pp. 1–11, Aug. 2017, doi: 10.1590/s1678-9946201759057.
[48] M. M. Alam, M. K. Khan, and N. Islam, “An overview of epidemiology of tuberculosis,” Mymensingh Med J, vol. 28, no. 1, pp. 259–266, 2019, [Online]. Available: https://www.researchgate.net/publication/343523793
[49] F. Hierink, E. A. Okiro, A. Flahault, and N. Ray, “The winding road to health: A systematic scoping review on the effect of geographical accessibility to health care on infectious diseases in low- and middle-income countries,” PLoS One, vol. 16, no. 1, p. e0244921, Jan. 2021, doi: 10.1371/journal.pone.0244921.
[50] P. M. Tukamuhebwa, P. Munyewende, N. M. Tumwesigye, J. Nabirye, and N. Ndlovu, “Health worker perspectives on barriers and facilitators of tuberculosis investigation coverage among index case contacts in rural Southwestern Uganda: a qualitative study,” BMC Infect. Dis., vol. 24, no. 1, p. 867, Aug. 2024, doi: 10.1186/s12879-024-09798-9.
[51] S. B. Marahatta et al., “Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers,” PLoS One, vol. 15, no. 1, pp. 1–18, 2020, doi: 10.1371/journal.pone.0227293.
[52] Z. M. Chun, J. Q. Jun, and H. Y. Yan, “The Spatiotemporal Dynamic Distributions of New Tuberculosis in Hangzhou, China,” Biomed. Environ. Sci., vol. 33, no. 4, pp. 277–281, 2020, doi: https://doi.org/10.3967/bes2020.038.
[53] M. A. Asemahagn, G. D. Alene, and S. A. Yimer, “Geographic Accessibility, Readiness, and Barriers of Health Facilities to Offer Tuberculosis Services in East Gojjam Zone, Ethiopia: A Convergent Parallel Design,” Res. Rep. Trop. Med., vol. Volume 11, pp. 3–16, Feb. 2020, doi: 10.2147/RRTM.S233052.
[54] H. E. Jenkins et al., “Geographic accessibility to health facilities predicts uptake of community-based tuberculosis screening in an urban setting,” Int. J. Infect. Dis., vol. 120, pp. 125–131, Jul. 2022, doi: 10.1016/j.ijid.2022.04.031.
[55] J.-Y. Lee, N. Kwon, G. Goo, and S. Cho, “Inadequate housing and pulmonary tuberculosis: a systematic review,” BMC Public Health, vol. 22, no. 1, p. 622, Dec. 2022, doi: 10.1186/s12889-022-12879-6.
[2] World Helath Organizatiaon, Global Tuberculosis Report 2024. 2024. [Online]. Available: https://iris.who.int/bitstream/handle/10665/379339/9789240101531-eng.pdf?sequence=1
[3] Kementrian Kesehatan RI, “Kasus TBC Tinggi Karena Perbaikan Sistem Deteksi dan Pelaporan.” Accessed: Nov. 24, 2024. [Online]. Available: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20240129/2644877/kasus-tbc-tinggi-karena-perbaikan-sistem-deteksi-dan-pelaporan/
[4] Dinas Kesehatan Provinsi Sulawesi Barat, “Upaya Penanggulangan Tuberkulosis di Sulawesi Barat: Langkah Menuju Bebas TBC 2030,” 2024. [Online]. Available: https://dinkes.sulbarprov.go.id/upaya-penanggulangan-tuberkulosis-di-sulawesi-barat-langkah-menuju-bebas-tbc-2030/
[5] F. Islam et al., “Factors Affecting Treatment Adherence Among Patients with Tuberculosis in Indonesia: Literature Review,” J. Public Heal. Pharm., vol. 4, no. 1, pp. 28–37, Mar. 2024, doi: 10.56338/jphp.v4i1.5022.
[6] A. Prameswari, “Urgensi Penanggulangan TBC di Indonesia.” Accessed: Nov. 24, 2024. [Online]. Available: https://rc-gerid.unair.ac.id/id/urgensi-penanggulangan-tbc-di-indonesia/
[7] M. S. Ramadhani, S. Suhartono, and O. Setiani, “Gambaran Sebaran Kasus Tuberkulosis Dalam Pendekatan Spasial Dan Temporal,” J. Kesehat. Masy., vol. 9, no. 4, pp. 529–540, Aug. 2021, doi: 10.14710/jkm.v9i4.30078.
[8] H. H. D. Lasari, I. Medyna, N. A. Fadillah, D. Rosadi, and R. Fakhriadi, “Spatio-temporal analysis of tuberculosis in Sungai Tabuk District, South Kalimantan, 2020-2021,” IOP Conf. Ser. Earth Environ. Sci., vol. 1239, no. 1, p. 012024, Sep. 2023, doi: 10.1088/1755-1315/1239/1/012024.
[9] Y. Yu, B. Wu, C. Wu, Q. Wang, D. Hu, and W. Chen, “Spatial-temporal analysis of tuberculosis in Chongqing, China 2011-2018,” BMC Infect. Dis., vol. 20, no. 1, p. 531, Dec. 2020, doi: 10.1186/s12879-020-05249-3.
[10] K. Chinpong et al., “Spatiotemporal Epidemiology of Tuberculosis in Thailand from 2011 to 2020,” Biology (Basel)., vol. 11, no. 5, p. 755, May 2022, doi: 10.3390/biology11050755.
[11] H. I. Zebua and I. G. N. M. Jaya, “Spatial Autoregressive Model of Tuberculosis Cases in Central Java Province 2019,” CAUCHY J. Mat. Murni dan Apl., vol. 7, no. 2, pp. 240–248, Mar. 2022, doi: 10.18860/ca.v7i2.13451.
[12] R. Tanjung, E. L. Mahyuni, N. Tanjung, O. S. Simarmata, J. Sinaga, and H. R. Nolia, “The Spatial Distribution of Pulmonary Tuberculosis in Kabanjahe District, Karo Regency, Indonesia,” Open Access Maced. J. Med. Sci., vol. 9, no. E, pp. 817–822, Sep. 2021, doi: 10.3889/oamjms.2021.6808.
[13] F. Fahdhienie, F. Y. Sitepu, and E. B. Depari, “Tuberculosis in Aceh Province, Indonesia: a spatial epidemiological study covering the period 2019–2021,” Geospat. Health, vol. 19, no. 2, Sep. 2024, doi: 10.4081/gh.2024.1318.
[14] S. Fitriyani and M. Sari, “Analisis Spasial Temporal Sosiodemografi Dan Variabilitas Iklim Terhadap Kejadian Tuberkulosis Paru BTA Positif di Provinsi Jawa Barat Tahun 2013-2017,” J. Untuk Masy. Sehat, vol. 5, no. 2, pp. 2715–8748, 2021, [Online]. Available: http://ejournal.urindo.ac.id/index.php/jukmas
[15] N. Hasnanisa, S. Prasetyo, and H. Yolanda, “Faktor-faktor Tuberkulosis Paru: Analisis Spasial,” Jikm, vol. 15, no. 3, pp. 107–118, 2023, [Online]. Available: https://jikm.upnvj.ac.id/index.php/home/article/view/466/160
[16] M. Tuntun, S. Aminah, and Yusrizal CH, “Distribution pattern and spatial analysis of factors for tuberculosis (TB) cases in Bandar Lampung City in 2022,” Bali Med. J., vol. 12, no. 1, pp. 50–58, Dec. 2022, doi: 10.15562/bmj.v12i1.3918.
[17] A. C. K. Nahak, I. A. T. Hinga, H. I. Ndoen, and Y. K. Samruth, “Spatial Analysis of Pulmonary Tuberculosis Incidence in Kupang City in 2019-2021,” J. Public Heal. Trop. Coast. Reg., vol. 7, no. 1, pp. 83–95, Apr. 2024, doi: 10.14710/jphtcr.v7i1.20682.
[18] D. S. Rosady, N. R. A. Zulfa, and S. B. Pratama, “Epidemiologic Spatial Analysis of a Tuberculosis Incidence in Bandung City in 2021,” Glob. Med. Heal. Commun., vol. 12, no. 1, pp. 31–36, Apr. 2024, doi: 10.29313/gmhc.v12i1.12410.
[19] A. F. Nurqanita et al., “Spatial and Epidemiological Analysis of Tuberculosis Incidence in Children in Palembang City in 2022,” J. Kesehat., vol. 17, no. 1, pp. 25–36, May 2024, doi: 10.23917/jk.v17i1.3004.
[20] T. B. Purnama, T. Kamigaki, M. Minsarnawati, and H. Oshitani, “Spatial Distribution of Tuberculosis in the Western Region of Java Island, Indonesia,” J. Heal. Sci. Med. Res., vol. 41, no. 1, p. 1, Dec. 2022, doi: 10.31584/jhsmr.2022889.
[21] D. N. S. Diba, B. Murti, and N. A. Setiyadi, “Spatial Analysis of Pulmonary Tuberculosis Risk in Surakarta , Central Java , Indonesia,” J. Epidemiol. Public Heal., vol. 09, no. 3, pp. 386–406, 2024, [Online]. Available: https://jepublichealth.com/index.php/jepublichealth/article/view/722/421
[22] P. Septiani, “Spatial Autocorrelation Analysis Of Pulmonary Tuberculosis Cases in Central Java Province,” J. Biometrika dan Kependud. (Journal Biometric Popul., vol. 13, no. 1, pp. 90–99, 2024, [Online]. Available: https://e-journal.unair.ac.id/JBK/article/view/50069/29295
[23] S. Khodijah and A. Prabawa, “Spatial Analysis of Risk Factors for Tuberculosis Incidence in South Jakarta City in 2022,” MPPKI Media Publ. Promosi Kesehat. Indones. " Indones. J. Heal. Promot., vol. 7, no. 6, pp. 1518–1524, 2024, [Online]. Available: https://jurnal.unismuhpalu.ac.id/index.php/MPPKI/article/view/5208/4018
[24] A. S. Cahyaningrum and N. A. Setiyadi, “Geo-Spatial Cluster Tuberkulosis of 2021-2023: Study in a District, Indonesia,” Indones. J. Glob. Heal. Res., vol. 6, no. 5, pp. 2863–2872, Nov. 2025, [Online]. Available: https://jurnal.globalhealthsciencegroup.com/index.php/IJGHR/article/view/3609/2610
[25] T. Puspita et al., “Spatial Variation of Tuberculosis Risk in Indonesia 2010-2019,” Heal. Sci. J. Indones., vol. 12, no. 2, pp. 104–110, Dec. 2021, doi: 10.22435/hsji.v12i2.5467.
[26] N. A. Mohidem, M. Osman, Z. Hashim, F. M. Muharam, S. Mohd Elias, and R. Shaharudin, “Association of sociodemographic and environmental factors with spatial distribution of tuberculosis cases in Gombak, Selangor, Malaysia,” PLoS One, vol. 16, no. 6, p. e0252146, Jun. 2021, doi: 10.1371/journal.pone.0252146.
[27] D. W. S. R. Wardani, L. Lazuardi, Y. Mahendradhata, and H. Kusnanto, “Pentingnya Analisis Cluster Berbasis Spasial dalam Penanggulangan Tuberkulosis di Indonesia,” Kesmas Natl. Public Heal. J., vol. 8, no. 4, p. 147, Nov. 2013, doi: 10.21109/kesmas.v0i0.391.
[28] Badan Pusat Statistik Sulawesi Barat, “Provinsi Sulawesi Barat dalam Angka,” 2024. [Online]. Available: https://sulbar.bps.go.id/id/publication/2024/02/28/8fdd58f5dce1137aaf1f1632/provinsi-sulawesi-barat-dalam-angka-2024.html
[29] Dinas Kesehatan Provinsi Sulawesi Barat, “Laporan Sistem Informasi Tuberkulosis,” 2024.
[30] SaTScanTM, “SaTScanTM Software for the spatial, temporal, and space-time scan statistics: ‘Download SaTScan For Windows.’” Accessed: Jul. 10, 2024. [Online]. Available: https://www.satscan.org/download_satscan.html
[31] I. Gwitira, N. Karumazondo, M. D. Shekede, C. Sandy, N. Siziba, and J. Chirenda, “Spatial patterns of pulmonary tuberculosis (TB) cases in Zimbabwe from 2015 to 2018,” PLoS One, vol. 16, no. 4, p. e0249523, Apr. 2021, doi: 10.1371/journal.pone.0249523.
[32] QGIS Development Team, “Download QGIS For Your Platform,” QGIS. Accessed: Nov. 17, 2023. [Online]. Available: https://www.qgis.org/download/
[33] Y.-P. Yeh, H.-J. Chang, J. Yang, S.-H. Chang, J. Suo, and T. H.-H. Chen, “Incidence of Tuberculosis in Mountain Areas and Surrounding Townships: Dose–Response Relationship by Geographic Analysis,” Ann. Epidemiol., vol. 15, no. 7, pp. 526–532, Aug. 2005, doi: 10.1016/j.annepidem.2004.08.005.
[34] M. Rezky, “Analisis Spasial Kejadian Tuberkulosis di Daerah Dataran Tinggi Kabupaten Gowa,” Universitas Islam Negeri Alauddin Makassar, 2017. [Online]. Available: https://repositori.uin-alauddin.ac.id/11438/1/MULI REZKY 70200113122.pdf
[35] M. SAITO et al., “Comparison of Altitude Effect on Mycobacterium Tuberculosis Infection Between Rural and Urban Communities in Peru,” Am. J. Trop. Med. Hyg., vol. 75, no. 1, pp. 49–54, Jul. 2006, doi: 10.4269/ajtmh.2006.75.49.
[36] K. T. Aulia and S. K. Yuniati, “The Effect of Population Density on The Risk of Tuberculosis in Densely Populated Environments,” J. Divers. Med. Res., vol. 1, no. 2, pp. 7–12, 2024, [Online]. Available: https://medicosphere.upnjatim.ac.id/index.php/medicosphere/article/view/96/29
[37] W. Hasan, “Penggunaan sistem informasi geografis untuk pemetaan sebaran kasus dan faktor risiko kejadian penyakit tb. Paru bta (+) di kabupaten majene,” J. Inf. Syst. Public Heal., vol. 4, no. 3, p. 40, Oct. 2021, doi: 10.22146/jisph.25863.
[38] S. E. Saqib and M. M. Ahmad, “Socio-economic determinants of the family history of pulmonary tuberculosis patients in Pakistan,” Dev. Pract., vol. 29, no. 1, pp. 103–114, Jan. 2019, doi: 10.1080/09614524.2018.1516737.
[39] H. Li, M. Ge, and M. Zhang, “Spatio-temporal distribution of tuberculosis and the effects of environmental factors in China,” BMC Infect. Dis., vol. 22, no. 1, p. 565, Dec. 2022, doi: 10.1186/s12879-022-07539-4.
[40] A. Baughman and E. Arens, “Indoor Humidity and Human Health-Part I: Literature Review of Health Effects of Humidity-Influenced Indoor Pollutants,” ASHRAE Trans., vol. 102, 1996, [Online]. Available: https://escholarship.org/uc/item/5kz1z9cg
[41] Y.-J. LIN and C.-M. LIAO, “Seasonal dynamics of tuberculosis epidemics and implications for multidrug-resistant infection risk assessment,” Epidemiol. Infect., vol. 142, no. 2, pp. 358–370, Feb. 2014, doi: 10.1017/S0950268813001040.
[42] A. G. Omonijo, O. Oguntoke, A. Matzarakis, and C. O. Adeofun, “A study of weather related respiratory diseases in eco-climatic zones,” African Rev. Phys., vol. 5, pp. 41–56, 2011, [Online]. Available: https://api.semanticscholar.org/CorpusID:33703549
[43] L. Xia et al., “Spatio-temporal analysis of socio-economic characteristics for pulmonary tuberculosis in Sichuan province of China, 2006–2015,” BMC Infect. Dis., vol. 20, no. 1, p. 433, Dec. 2020, doi: 10.1186/s12879-020-05150-z.
[44] N. A. Mohidem, M. Osman, Z. Hashim, F. M. Muharam, S. Mohd Elias, and A. Ma’pol, “Spatial Analysis of Identifying the Association between Risk Factors and Tuberculosis Cases: A Review,” Educ. J. Sci. Math. Technol., vol. 12, no. 1, pp. 24–34, Aug. 2024, doi: 10.37134/ejsmt.vol12.1.4.2025.
[45] T. K. A. Teibo, R. L. de P. Andrade, R. J. Rosa, R. B. V. Tavares, T. Z. Berra, and R. A. Arcêncio, “Geo-spatial high-risk clusters of Tuberculosis in the global general population: a systematic review,” BMC Public Health, vol. 23, no. 1, p. 1586, Aug. 2023, doi: 10.1186/s12889-023-16493-y.
[46] T. A. Campelo et al., “Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil,” Rev. Inst. Med. Trop. Sao Paulo, vol. 62, no. October 2019, pp. 1–10, 2020, doi: 10.1590/s1678-9946202062004.
[47] B. A. Cardoso et al., “Environmental aspects related to tuberculosis and intestinal parasites in a low-income community of the Brazilian Amazon,” Rev. Inst. Med. Trop. Sao Paulo, vol. 59, no. May, pp. 1–11, Aug. 2017, doi: 10.1590/s1678-9946201759057.
[48] M. M. Alam, M. K. Khan, and N. Islam, “An overview of epidemiology of tuberculosis,” Mymensingh Med J, vol. 28, no. 1, pp. 259–266, 2019, [Online]. Available: https://www.researchgate.net/publication/343523793
[49] F. Hierink, E. A. Okiro, A. Flahault, and N. Ray, “The winding road to health: A systematic scoping review on the effect of geographical accessibility to health care on infectious diseases in low- and middle-income countries,” PLoS One, vol. 16, no. 1, p. e0244921, Jan. 2021, doi: 10.1371/journal.pone.0244921.
[50] P. M. Tukamuhebwa, P. Munyewende, N. M. Tumwesigye, J. Nabirye, and N. Ndlovu, “Health worker perspectives on barriers and facilitators of tuberculosis investigation coverage among index case contacts in rural Southwestern Uganda: a qualitative study,” BMC Infect. Dis., vol. 24, no. 1, p. 867, Aug. 2024, doi: 10.1186/s12879-024-09798-9.
[51] S. B. Marahatta et al., “Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers,” PLoS One, vol. 15, no. 1, pp. 1–18, 2020, doi: 10.1371/journal.pone.0227293.
[52] Z. M. Chun, J. Q. Jun, and H. Y. Yan, “The Spatiotemporal Dynamic Distributions of New Tuberculosis in Hangzhou, China,” Biomed. Environ. Sci., vol. 33, no. 4, pp. 277–281, 2020, doi: https://doi.org/10.3967/bes2020.038.
[53] M. A. Asemahagn, G. D. Alene, and S. A. Yimer, “Geographic Accessibility, Readiness, and Barriers of Health Facilities to Offer Tuberculosis Services in East Gojjam Zone, Ethiopia: A Convergent Parallel Design,” Res. Rep. Trop. Med., vol. Volume 11, pp. 3–16, Feb. 2020, doi: 10.2147/RRTM.S233052.
[54] H. E. Jenkins et al., “Geographic accessibility to health facilities predicts uptake of community-based tuberculosis screening in an urban setting,” Int. J. Infect. Dis., vol. 120, pp. 125–131, Jul. 2022, doi: 10.1016/j.ijid.2022.04.031.
[55] J.-Y. Lee, N. Kwon, G. Goo, and S. Cho, “Inadequate housing and pulmonary tuberculosis: a systematic review,” BMC Public Health, vol. 22, no. 1, p. 622, Dec. 2022, doi: 10.1186/s12889-022-12879-6.
Published
2025-07-01
How to Cite
Islam, F., Ahmad, H., Akbar, F., Khaer, A., Suryadi, I., Syukri, M., & Ramadhan, K. (2025). Spatio-Temporal Analysis of Tuberculosis Clusters in a Region of Topographic Diversity: A Case Study from West Sulawesi Province, Indonesia. Journal of Public Health and Pharmacy, 5(2), 383-393. https://doi.org/10.56338/jphp.v5i2.6762
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